NSW are chasing their first State of Origin clean sweep since the 2000 series but will have to do so with a new halves combination and another change in the front row.
And they'll have to do it by winning three games in Queensland for the first time in Origin history after the game was relocated from Newcastle to the Gold Coast due to the worsening COVID situation in Sydney.
Eels playmaker Mitch Moses makes his Origin debut in Game Three and will partner with Raiders pivot Jack Wighton, who has seen limited game time this series off the bench.
The Blues are already ahead of another record set by their NSW forebears in 2000, their 70-point advantage after two games exceeding the 62-point margin NSW enjoyed in winning that series.
Paul Green's first series in charge of the Maroons has been a nightmare thus far but the return of Kalyn Ponga at fullback presents a chink of light at the end of a very dark tunnel.
Ponga's speed and creativity, plus the pace of debutant Hamiso Tabuai-Fidow, give the Queenslanders a shot at adding to their paltry tally of just one try so far this series.
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The rundown
Team news
Blues: No late changes for Brad Fittler's team.
The loss of halves Nathan Cleary (shoulder) and Jarome Luai (knee) is a significant blow and the choice of the Moses/Wighton combination is designed to cause as little disruption to the game plan as possible.
Api Koroisau takes over Wighton's role in the No.14 jersey while the loss of prop Daniel Saifiti (ribs) sees Storm veteran Dale Finucane promoted to the starting side and has also been named vice-captain.
Wests Tigers youngster Stefano Utoikamanu was left out 24 hours before kick-off when the squad was reduced to 19 players. Clint Gutherson was the last man cut an hour before game time and Nicho Hynes is 18th man.
The playmakers set to take charge in State of Origin III
Maroons: No late changes for Paul Green on game day.
Forward Jai Arrow has been suspended for game three and is facing a $35,000 fine for allegedly breaching COVID-19 protocols by bringing an "unregistered guest" into Maroons camp.
Arrow has been accused of breaking NRL biosecurity rules by inviting the guest into the team hotel and was served with a breach notice by the game's governing body on Thursday.
Green confirmed on Monday that Tino Fa'asuamaleaui would return to the starting side at lock and Thomas Flegler will join the bench.
David Fifita failed in his challenge at the judiciary and will sit out the series finale with 18th man Francis Molo taking Fifita's place on the interchange.
Key personnel changes have resulted in a speedier, more creative backline with Kalyn Ponga returning, Valentine Holmes shifting to the wing and Hamiso Tabuai-Fidow handed his debut in the centres.
The North Queensland teen's call-up means Kurt Capewell can shift to a more suitable spot in the back row, adding starch to the pack at the same time, while the return from injury of AJ Brimson in the No.14 role will also provide much-needed spark.
The theme continues with the promotion of bench utility Ben Hunt to starting dummy-half in place of hard-working No.9 and club teammate Andrew McCullough.
Cowboys forward Coen Hess was added to the squad two days out from the game after spending time in the Maroons camp already this series. Hess was cut an hour before kick-off and Kurt Mann is 18th man.
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Key match-up
Mitch Moses v Daly Cherry-Evans: The consensus is that the time is very much now for the 26-year-old Eels play-maker and he will be desperate to reward the faith shown in him.
The series may be won but there is still plenty of pressure on Moses as he tried to fill Nathan Cleary's very large boots.
The Queensland captain has 15 Origin games to his credit but Cherry-Evans is under just as much pressure as the Blues debutant after uncharacteristically losing his cool in game two.
Stat attack
Queensland's difficulty in scoring points is starkly illustrated by the fact they have only managed a single line break per match so far this series while the Blues have accumulated 17.
The tackle breaks category is slightly more encouraging with the Maroons tallying 68 busts to NSW's 101.
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